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1997 1998 1999 Provided by/avec le support de :     S-221 87 Lund Sweden ARLS information : Myrna Mansson Get the paper version from your local Marketing representative. Find the address on the net at http://www.astrazeneca.com/astra/world AstraZeneca Respiratory Literature Service (see table of content) For many years, AstraZeneca Draco laboratories have brought to the asthmologist community an excellent "Respiratory Literature Service" (ARLS) with an alert to new references, selected summaries and comments by a group of experts. In 1997, AstraZeneca is extending this concrete service with Asmanet in order to take advantage of the Internet capabilities. The following comments have been edited ( HTML format) to smooth the reading with hypertext links to integrate the comment in the Asmanet server and the worldwide distributed library on asthma, such as : abstract of the commented paper, references as seen on Medline and others, author's e-mail ... ARLS  N°5 (july 2000)    11 new expert comments ARLS  N°4 (june 2000)    11 new expert comments ARLS  N°3 (april 2000)    10 new expert comments ARLS 1999 N° 2 (june 1999)    16 new expert comments ARLS 1999 N° 1 (march 1999)    10 new expert comments ARLS 1998 N° 6 (december 1998)    9 new expert comments ARLS 1998 N° 5 (october 1998)    Alerts to newly published references, selected summaries and 8 new comments by a group of experts : Professor Geddes (England), Professor Godard (France), Ass. Professor Rosenhall (Sweden), and Professor Toogood (Canada). ARLS 1998 N° 4 (august 1998) Corticosteroids Inhalation formulations ß2-agonists Theophyline Antileukotrienes COPD  ARLS 1998 N° 3 (may 1998) Childhood asthma acute asthma exercise-induced asthma rhinitis new insights in established treatments (corticosteroids, bambuterol, formoterol, salmeterol, theophylline, H1-antagonists) new drug treatments (seratrodast, antileukotrienes, COX-2 inhibitors, immunotherapy) ARLS 1998 N° 2 (march 1998) Management of accute asthma Costs associated with with asthma Pregnancy and asthma Drug treatment of respiratory diseases ARLS 1998 N° 1 (january 1998) Preference study Costs of Asthma Alternative treatments Leukotriene antagonists Ipratropium     ARLS 1997 N° 6   ARLS 1997 N° 5   ARLS 1997 N° 4   ARLS 1997 N° 3   ARLS 1997 N° 2   ARLS 1997 N° 1   AstraZeneca Draco laboratories is also supporting the European Federation of Asthma and Allergy Associations which can be seen at http://www.efanet.org/

Six times per year, you will find here scientific commentaries about asthma and asthma related topics.

ARLS  N°4 : Experts comments on 11 new subjects.

1. Effects of formoterol in apparently poorly reversible chronic obstructive pulmonary disease. 

2. Exacerbations of asthma - A descriptive study of 425 severe exacerbations 

3. Once-daily budesonide inhalation suspension for the treatment of persistent asthma in infants and young children 

4. Administration of budesonide once daily by means of Turbuhaler ® to subjects with stable asthma. 

5. Oral corticosteroids in patients admitted to hospital with exacerbations of chronic obstructive pulmonary disease: a prospective randomised controlled trial 

6. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. 

7. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. 

8. Underdiagnosis and undertreatment of asthma in the elderly 

9. Incidence and prevalence of asthma among adult Finnish men and women of the Finnish Twin Cohort from 1975 to 1990, and their relation to hay fever and chronic bronchitis. 

10. Prospective multicenter study of relapse following treatment for acute asthma among adults presenting to the emergency department 

11. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics

ARLS  N°4 : Experts comments on 11 new subjects.

1. An evaluation of zafirlukast in the treatment of asthma with exploratory subset analyses.

2. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial.

3. Congenital malformations after the use of inhaled budesonide in early pregnancy

4. Comparison of the efficacy of budesonide and fluticasone propionate aqueous nasal spray for once daily treatment of perennial allergic rhinitis

5. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking

6. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease.

7. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease.

8. Nebulized lidocaine in the treatment of severe asthma in children: a pilot study

9. Differences between asthma exacerbations and poor asthma control

10. Cigarette smoking and asthma symptom severity among adult asthmatics

11. The economic burden of asthma: direct and indirect costs in Switzerland.direct and indirect costs in Switzerland.

ARLS  N°3 : Experts comments on 10 new subjects.

1. Comparison of oral bambuterol and inhaled salmeterol in patients with symptomatic asthma and using inhaled corticosteroids.

2. Benefits of high-dose i.v. immunoglobulin in patients with severe steroid-dependent asthma.

3. Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids.

4. Peak flow variation in childhood asthma: correlation with symptoms, airways obstruction, and hyperresponsiveness during long term treatment with inhaled corticosteroids

5. First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma

6. Starting with a higher dose of inhaled corticosteroids in primary care asthma treatment.

7. Glucocorticoid insensitive asthma: a one year clinical follow up pilot study.

8. Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials.

9. An inhaled steroid improves markers of airway inflammation in patients with mild asthma.

10. Long-term influence of inhaled corticosteroids on bone metabolism and density. Are biological markers predictors of bone loss?

ARLS 1999 N° 2 : Experts comments on 14 new subjects.

1. Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis
2. Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
3. Effect of nebulized ipratropium on the hospitalization rates of children with asthma
4. Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomised, placebo-controlled trial: The rist results of ETAC
5. Classification of asthma severity: should the international guidelines be changed?
6. Long-term effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
7. The effects of regular inhaled formoterol, budesonide and placebo on mucosal inflammation and clinical indices in mild asthma.
8. Do inhaled steroids cause osteoporosis?
9. A comparison of two long-acting b-agonists, oral bambuterol and inhaled salmeterol in the treatment of moderate to severe asthmatic patients with nocturnal symptoms
10. Sex differences in the use of asthma drugs: Cross sectional study
11. Comparison of 2.5 vs 7.5 mg of inhaled albuterol in the treatment of acute asthma
12. Classification of asthma severity: Should the international guidelines be changed?
13. The effects of regular inhaled formeterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma
14. Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma
15. Long term effects of inhaled corticosteroids in COPD: a meta analysis
16. Dietary anti oxidants and magnesium in type 1 brittle asthma: a case control study

ARLS 1999 N° 1 : Experts comments on 10 new subjects.

1. Low-dose formoterol Turbuhaler® (Oxis®) b.i.d., a 3-month placebo-controlled comparison with terbutaline (q.i.d.)
2. Salmeterol prevents aspirin-induced attacks of asthma and interferes with eicosanoid metabolism.
3. Tolerability to high doses of formoterol and terbutaline via Turbuhaler® for 3 days in stable asthmatic patients
4. Fluticasone propionate 750 µg/day versus beclomethasone dipropionate 1500 µg/day: comparison of efficacy and adrenal function in paediatric asthma
5. Association of inhaled corticosteroid use with cataract extraction in elderly patients
6. Effect of theophylline withdrawal on airway inflammation in asthma
7. Neuropharmacologic treatment of bronchial asthma with the antidepressant tianeptine: a double-blind, crossover placebo-controlled study.
8. Clinical benefits and cost reduction associated with a comprehensive asthma management programme at a managed care organisation
9. Long term trends in quality of life from the FACET study.
10. A 15-year follow-up study of ventilatory function in adults with asthma

ARLS 1998 N° 6 : Experts comments on 9 new subjects.

1. Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation
2. Treatment of acute asthmatic exacerbations with an increased dose of inhaled steroid
3. Clinical efficacy of sublingual-swallow immunotherapy: a double-blind, placebo-controlled trial of a standardised five-grass-pollen extract in rhinitis
4. Cost-effectiveness of fluticasone and budesonide in patients with moderate asthma
5. Montelukast, a potent leukotriene receptor antagonist, causes dose-related improvements in chronic asthma
6. Bambuterol is a more cost-effective treatment than salmeterol in asthma patients with nocturnal symptoms
7. Effects of orally inhaled budesonide in seasonal allergic rhinitis
8. Randomised controlled trial of inhaled corticosteroids in patients with chronic obstructive pulmonary disease
9. Zafirlukast and Churg-Strauss syndrome

ARLS 1998 N° 5 : Experts comments on 8 new subjects.

1. Comparative clinical study of inhaled beclomethasone dipropionate and triamcinolone acetonide in persistent asthma.
2. Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma
3. Prednisolone in acute childhood asthma: clinical responses to three dosages
4. Computer-based models to identify high-risk children with asthma
5. Once-daily budesonide in mild asthma
6. Growth in asthmatic children treated with fluticasone propionate
7. Dose-related response to inhaled fluticasone propionate in patients with methacholine-induced bronchial hyperresponsiveness: a double-blind, placebo-controlled study
8. Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment

ARLS 1998 N° 4 : Experts comments on 7 new subjects.

1. Duration of growth suppressive effects of regular inhaled corticosteroids
2. Prospective, double-blind, placebo-controlled, multicentre study on the effect of high-dose, intravenous immunoglobulin in children and adolescents with severe bronchial asthma.
3. Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast
4. Neuropsychological and behavioural changes in asthmatic children treated with beclomethasone diproprionate vs theophylline
5. Short-term treatment with budesonide does not improve hyperresponsiveness to adenosine 5’-monophosphate in COPD
6. The US Lung Health Study   
7. Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide

ARLS 1998 N° 3 : Experts comments on 7 new subjects.

1. Prevalence of asthma symptoms, diagnosis and treatment in 12-14 year old children across Great Britain (International study of asthma and allergies in childhood, ISAAC UK)
2. Perinatal factors and atopic disease in childhood
3. Dose-related protection of exercise bronchoconstriction by montelukast, a cysteinyl leukotriene-receptor antagonist, at the end of a once-daily dosing interval
4. A comparison of beclomethasone, salmeterol and placebo in children with asthma
5. Exercise-induced asthma
6. Nebulized wet aerosol treatment in emergency department - is it essential? Comparison with large spacer device for metered-dose inhaler
7. The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma

ARLS 1998 N° 2 : Experts comments on 7 new subjects.

1. The safety of asthma and allergy in medications during pregnancy
2. Effect of inhaled formoterol and budesonide on exacerbations of asthma
3. A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma
4. A comparison between emergency diagnostic and treatment unit (EDTU) and inpatient care in the management of acute asthma
5. Association between b 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics
6. Comparative lung delivery of salbutamol given via Turbuhaler and Diskus dry powder inhaler devices
7. Esophageal candidiasis as a complication of inhaled corticosteroids

ARLS 1998 N° 1 : Experts comments on 8 new subjects.

1. A patient preference study comparing Turbuhaler with Diskus, two multi-dose dry powder inhaler devices
2. Results of the first U.S. double-blind, placebo-controlled, multicenter clinical study in asthma with pranlukast, a novel leukotriene receptor antagonist
3. Nebulized salbutamol with and without ipratropium bromide in the treatment of acute asthma.
4. A 1-year, placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults
5. Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients
6. Is asthma treatment affordable in developing countries ?
7. A national estimate of the economic costs of asthma
8. Improvement of bronchial hyperresponsiveness in asthmatic children treated for concomitant sinusitis

. ARLS 1997 N° 6 : Experts comments on 6 new subjects.

1. Osteoporotic vertebral fractures in a man under highdose inhaled glucocorticoid therapy
2. Use of inhaled corticosteroids and the risk of cataracts
3. A randomized, double-blind dose reduction study to compare the minimal effect of dose of budesonide Turbuhaler and fluticasone proionate Diskhaler.
4. Pranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study asthma
5. Salmeterol. A review of its pharmacological properties and clinical efficacy in the management of children with asthma
6. The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma.

ARLS 1997 N° 5 : Experts comments on 7 new subjects.

1. Inhibition of allergen-induced airway obstruction and leukotriene generation in atopic asthmatic subjects by the leukotriene biosynthesis inhibitor BAYx1005
2. Effect of long term treatment with salmeterol on asthma control: a double blind, randomised crossover study.
3. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma.
4. Adult patients may outgrow their asthma. A 25 year follow-up study
5. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma.
6. Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid
7. Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma

ARLS 1997 N° 4 : Experts comments on 7 new subjects.

1. Inhaled steroids and the risk of hospitalization for asthma
2. A controlled trial of immunotherapy for asthma in allergic children
3. Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma: a randomized, double-blind, placebo-controlled trial
4. Impact of nurse-led home management training programme in children admitted to hospital with acute asthma: a ramdomised controlled study.
5. Montelukast causes prolonged, potent leukotriene D4-receptor antagonism in the airways of patients with asthma
6. The clinical efficacy of combination nebulized anticholinergic and adrenergic bronchodilators vs nebulized adrenergic bronchodilator in acute asthma
7. Adrenal suppression with chronic dosing of fluticasone propionate compared with budesonide in adult astmatic patients

ARLS 1997 N° 3 : Experts comments on 8 new subjects.

1. Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device
2. Bronchodilators and acute cardiac death
3. Adult asthma and gastro-oesophageal reflux: the effects of omeprazole therapy on asthma
4. Dose-response of inhaled drugs in asthma: an update
5. An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled b2-agonist
6. Knemometry, urine cortisol excretion, and measures of the insulin-like growth factor axis and collagen turnover in children treated with inhaled glucocorticosteroids
7. Comparison of short courses of oral prednisolone and fluticasone propionate in the treatment of adults with acute exacerbations of asthma in primary care
8. Changes in bone markers in children with asthma during inhaled budesonide and nedocromil treatments

ARLS 1997 N° 2 : Experts comments on 5 new subjects.

1. Effectiveness of fluticasone propionate
2. Comparison of budesonide via Turbohaler and fluticasone propionate via disc-inhaler
3. The effect of the menstrual cycle on asthma presentations in the emergency department
4. Effects of prednisolone on bone turnover in patients with corticosteroid resistant asthma
5. A risk-benefit assessment of methotrexate in cortico-steroid dependent asthma

AstraZeneca Respiratory Literature Service : Experts Comments on :

1. A 12-week dose-ranging study of fluticasone propionate powder in the treatment of asthma
2. Use of oral corticosteroids in the community and the prevention of secondary osteoporosis: a cross sectional study
3. A placebo-controlled multicenter study of auranofin in the treatment of patients with corticosteroid-dependent asthma
4. Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study
5. Effects of regular salmeterol on lung function and exercise capacity in patients with chronic obstructive airways disease
6. Asthma treatment in pregnancy: a randomized controlled study

. ARLS   Congrès Conçue et réalisée par: Michel Godard (at) Top
Date de création: 1er Mars 1996 -Dernière mise à jour: 19/08/00
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